NHS-PEG4-(m-PEG4)3-ester


Catalog No. Size PriceQuantity
M32678-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

NHS-PEG4-(m-PEG4)3-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1333154-70-3

Molecular Weight: 1363.54

Formula: C60H110N6O28

Chemical Name: 2,5-dioxopyrrolidin-1-yl 4-[(14-{[1,3-bis({2-[(2,5,8,11-tetraoxatridecan-13-yl)carbamoyl]ethoxy})-2-({2-[(2,5,8,11-tetraoxatridecan-13-yl)carbamoyl]ethoxy}methyl)propan-2-yl]carbamoyl}-3,6,9,12-tetraoxatetradecan-1-yl)carbamoyl]butanoate

Smiles: COCCOCCOCCOCCNC(=O)CCOCC(COCCC(=O)NCCOCCOCCOCCOC)(COCCC(=O)NCCOCCOCCOCCOC)NC(=O)CCOCCOCCOCCOCCNC(=O)CCCC(=O)ON1C(=O)CCC1=O

InChiKey: CPFQBAXMDMJPOZ-UHFFFAOYSA-N

InChi: InChI=1S/C60H110N6O28/c1-75-25-28-83-41-44-87-37-33-80-22-14-62-53(68)9-18-91-49-60(50-92-19-10-54(69)63-15-23-81-34-38-88-45-42-84-29-26-76-2,51-93-20-11-55(70)64-16-24-82-35-39-89-46-43-85-30-27-77-3)65-56(71)12-17-78-31-36-86-47-48-90-40-32-79-21-13-61-52(67)5-4-6-59(74)94-66-57(72)7-8-58(66)73/h4-51H2,1-3H3,(H,61,67)(H,62,68)(H,63,69)(H,64,70)(H,65,71)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.

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