Description
RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM.
Product information
CAS Number: 2414374-53-9
Molecular Weight: 339.39
Formula: C18H21N5O2
Chemical Name: 3-(2H-1,3-benzodioxol-5-yl)-N-[3-(dimethylamino)propyl]pyrazolo[1,5-a]pyrimidin-5-amine
Smiles: CN(C)CCCNC1C=CN2N=CC(=C2N=1)C1=CC2OCOC=2C=C1
InChiKey: DQYRQFLRDJTHQM-UHFFFAOYSA-N
InChi: InChI=1S/C18H21N5O2/c1-22(2)8-3-7-19-17-6-9-23-18(21-17)14(11-20-23)13-4-5-15-16(10-13)25-12-24-15/h4-6,9-11H,3,7-8,12H2,1-2H3,(H,19,21)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
RET-IN-3 exhibits 16 and 410 fold selectivity compared to wt-RET and KDR, respectively.
Products are for research use only. Not for human use.
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