Thiol-PEG3-phosphonic acid


Catalog No. Size PriceQuantity
M32700-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Thiol-PEG3-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1360716-36-4

Molecular Weight: 274.27

Formula: C8H19O6PS

Chemical Name: (2-{2-[2-(2-sulfanylethoxy)ethoxy]ethoxy}ethyl)phosphonic acid

Smiles: OP(O)(=O)CCOCCOCCOCCS

InChiKey: UBKOBPQABCOCDH-UHFFFAOYSA-N

InChi: InChI=1S/C8H19O6PS/c9-15(10,11)7-5-13-3-1-12-2-4-14-6-8-16/h16H,1-8H2,(H2,9,10,11)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.

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