Description
Proctolin is an endogenous pentapeptide that acts as an excitatory neuromodulator.
Product information
CAS Number: 57966-42-4
Molecular Weight: 648.75
Formula: C30H48N8O8
Chemical Name: (2S,3R)-2-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamido]-3-(4-hydroxyphenyl)propanamido]-4-methylpentanoyl]pyrrolidin-2-yl]formamido}-3-hydroxybutanoic acid
Smiles: CC(C)C[C@H](NC(=O)[C@H](CC1C=CC(O)=CC=1)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(O)=O
InChiKey: KKUPPLMEDQDAJX-UEHMALFGSA-N
InChi: InChI=1S/C30H48N8O8/c1-16(2)14-22(28(44)38-13-5-7-23(38)27(43)37-24(17(3)39)29(45)46)36-26(42)21(15-18-8-10-19(40)11-9-18)35-25(41)20(31)6-4-12-34-30(32)33/h8-11,16-17,20-24,39-40H,4-7,12-15,31H2,1-3H3,(H,35,41)(H,36,42)(H,37,43)(H,45,46)(H4,32,33,34)/t17-,20+,21+,22+,23+,24+/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Proctolin can increase the frequency of action potentials, increase the amplitude of muscle contraction, and initiate activity in quiescent systems. In the arthropods, Proctolin acts as a neuromodulator and possibly as a neurohormone. It does not appear to function as a conventional neurotransmitter. Proctolin is a pentapeptide with the mature peptide of RYLPT, and it is the first insect neuropeptide to be sequenced and chemically characterized. The first identification of a Proctolin precursor gene is CG7105 in D. melanogaster. Although a previous study showed that Proctolin is absent in B. mori, this pentapeptide is recently identified in a proteomic analysis of B. mori wings. However, the Bombyx Proctolin gene does not produce a mature peptide because cleavage sites are not present at the N-terminal and C-terminal of the RYLPT sequence, and a similar gene is observed in C. suppressalis. Therefore, a true Proctolin has been considered to be not observed in B. mori and C. suppressalis.
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