MPG, HIV related

MPG, HIV related is 27-aa peptide, derived from both the nuclear localisation sequence of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41 and is a potent delivery agent for the generalised delivery of nucleic acids and of oligonucleotides into cultured cells.

Product information

CAS Number: 395069-92-8

Molecular Weight: 2766.22

Formula: C126H201N35O33S

Chemical Name: (2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-6-amino-2-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S,3R)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-(2-aminoacetamido)propanamido]-4-methylpentanamido]-3-phenylpropanamido]-4-methylpentanamido]acetamido}-3-phenylpropanamido]-4-methylpentanamido]acetamido}propanamido]propanamido]acetamido}-3-hydroxypropanamido]-3-hydroxybutanamido]-4-(methylsulfanyl)butanamido]acetamido}propanamido]-3-(1H-indol-3-yl)propanamido]-3-hydroxypropanamido]-4-carbamoylbutanoyl]pyrrolidin-2-yl]formamido}hexanamido]-3-hydroxypropanamido]hexanamido]-5-carbamimidamidopentanamido]hexanamido]-3-methylbutanoic acid

Smiles: CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(O)=O

InChiKey: MHPZQFOMDFEKNP-UVMOKRMMSA-N

InChi: InChI=1S/C126H201N35O33S/c1-66(2)51-86(154-116(184)89(54-75-31-17-15-18-32-75)144-100(170)62-139-110(178)87(52-67(3)4)155-117(185)90(55-76-33-19-16-20-34-76)156-115(183)88(53-68(5)6)152-106(174)72(11)140-97(167)57-130)109(177)138-60-99(169)141-71(10)105(173)143-70(9)104(172)136-61-101(171)145-92(63-162)121(189)160-103(74(13)165)123(191)150-84(44-50-195-14)108(176)137-59-98(168)142-73(12)107(175)153-91(56-77-58-135-79-36-22-21-35-78(77)79)118(186)158-94(65-164)120(188)151-85(42-43-96(131)166)124(192)161-49-30-41-95(161)122(190)149-81(38-24-27-46-128)113(181)157-93(64-163)119(187)148-80(37-23-26-45-127)111(179)147-83(40-29-48-134-126(132)133)112(180)146-82(39-25-28-47-129)114(182)159-102(69(7)8)125(193)194/h15-22,31-36,58,66-74,80-95,102-103,135,162-165H,23-30,37-57,59-65,127-130H2,1-14H3,(H2,131,166)(H,136,172)(H,137,176)(H,138,177)(H,139,178)(H,140,167)(H,141,169)(H,142,168)(H,143,173)(H,144,170)(H,145,171)(H,146,180)(H,147,179)(H,148,187)(H,149,190)(H,150,191)(H,151,188)(H,152,174)(H,153,175)(H,154,184)(H,155,185)(H,156,183)(H,157,181)(H,158,186)(H,159,182)(H,160,189)(H,193,194)(H4,132,133,134)/t70-,71-,72-,73-,74+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,102-,103-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

MPG, HIV related is 27-aa peptide vector, derived from both the nuclear localisation sequence of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41 and is a potent delivery agent for the generalised delivery of nucleic acids and of oligonucleotides into cultured cells and for gene therapy. MPG enables complete expression of the gene produces encoded by the plasmids it delivers into cultured cell.

Products are for research use only. Not for human use.