Description
SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis.
Product information
CAS Number: 956613-01-7
Molecular Weight: 483.58
Formula: C28H25N3O3S
Chemical Name: 4-[2-(4-methanesulfonyl-2-methylphenyl)-5-(6-methoxynaphthalen-2-yl)-1-methyl-1H-imidazol-4-yl]pyridine
Smiles: CC1=CC(=CC=C1C1=NC(=C(C2=CC3=CC=C(C=C3C=C2)OC)N1C)C1C=CN=CC=1)S(C)(=O)=O
InChiKey: ZDSNJSQTPLXCSG-UHFFFAOYSA-N
InChi: InChI=1S/C28H25N3O3S/c1-18-15-24(35(4,32)33)9-10-25(18)28-30-26(19-11-13-29-14-12-19)27(31(28)2)22-6-5-21-17-23(34-3)8-7-20(21)16-22/h5-17H,1-4H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 9.62 mg/mL (19.89 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SB-633825 inhibits TIE2 Tyrosine-protein kinase (TIE2), lymphocyte-oriented kinase (LOK; STK10) and breast tumor kinase (Brk; PTK6). SB-633825 inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity at 0.1 µM.
Products are for research use only. Not for human use.
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