Description
SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton.
Product information
CAS Number: 340316-62-3
Molecular Weight: 377.21
Formula: C15H9BrN2O3S
Chemical Name: (5E)-1-(3-bromophenyl)-5-[(furan-2-yl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
Smiles: O=C1/C(=C/C2=CC=CO2)/C(=O)NC(=S)N1C1=CC(Br)=CC=C1
InChiKey: MVFJHEQDISFYIS-XYOKQWHBSA-N
InChi: InChI=1S/C15H9BrN2O3S/c16-9-3-1-4-10(7-9)18-14(20)12(13(19)17-15(18)22)8-11-5-2-6-21-11/h1-8H,(H,17,19,22)/b12-8+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SMIFH2 (25 uM; 1-16 hours) induces dynamic cytoskeletal remodelling in U2OS cells. SMIFH2 (25 μM) reduces p300, mDia2 and p53 levels in a proteasome-independent manner. SMIFH2 reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism that influences remodelling of the cytoskeleton.
Products are for research use only. Not for human use.
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