Description
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease.
Product information
CAS Number: 2234272-10-5
Molecular Weight: 275.31
Formula: C16H13N5
Chemical Name: 4-[4-(1H-imidazol-1-yl)phenyl]-N-(prop-2-yn-1-yl)pyrimidin-2-amine
Smiles: C#CCNC1=NC(=CC=N1)C1C=CC(=CC=1)N1C=NC=C1
InChiKey: QKHQFSQJQKGFAA-UHFFFAOYSA-N
InChi: InChI=1S/C16H13N5/c1-2-8-18-16-19-9-7-15(20-16)13-3-5-14(6-4-13)21-11-10-17-12-21/h1,3-7,9-12H,8H2,(H,18,19,20)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
AP-C5 shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue. AP-C5 potentiates cAMP signaling by PDE inhibition. AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum.
Products are for research use only. Not for human use.
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