Nitecapone


Catalog No. Size PriceQuantity
M32987-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation.

Product information

CAS Number: 116313-94-1

Molecular Weight: 265.22

Formula: C12H11NO6

Chemical Name: 3-[(3,4-dihydroxy-5-nitrophenyl)methylidene]pentane-2,4-dione

Smiles: CC(=O)C(=CC1=CC(=C(O)C(O)=C1)[N+]([O-])=O)C(C)=O

InChiKey: UPMRZALMHVUCIN-UHFFFAOYSA-N

InChi: InChI=1S/C12H11NO6/c1-6(14)9(7(2)15)3-8-4-10(13(18)19)12(17)11(16)5-8/h3-5,16-17H,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.

In Vivo:

Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats.

Products are for research use only. Not for human use.

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