Description
ADPM06, a lead candidate azadipyrromethene, is a novel nonporphyrin photodynamic therapeutic (PDT) agent. ADPM06 exhibits IC50 values in the micro-molar range in human tumor cells and induces apoptosis.
Product information
CAS Number: 490035-90-0
Molecular Weight: 715.19
Formula: C34H24BBr2F2N3O2
Chemical Name: 5,11-dibromo-2,2-difluoro-4,12-bis(4-methoxyphenyl)-6,10-diphenyl-1λ⁵,3,8-triaza-2-boratricyclo[7.3.0.0³,⁷]dodeca-1(12),4,6,8,10-pentaen-1-ylium-2-uide
Smiles: COC1C=CC(=CC=1)C1=C(Br)C(=C2N=C3C(C4C=CC=CC=4)=C(Br)C(C4C=CC(=CC=4)OC)=[N+]3[B-](F)(F)N12)C1C=CC=CC=1
InChiKey: YVKIKMDAXWFEJI-UHFFFAOYSA-N
InChi: InChI=1S/C34H24BBr2F2N3O2/c1-43-25-17-13-23(14-18-25)31-29(36)27(21-9-5-3-6-10-21)33-40-34-28(22-11-7-4-8-12-22)30(37)32(42(34)35(38,39)41(31)33)24-15-19-26(44-2)20-16-24/h3-20H,1-2H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
The efficacy of ADPM01 is completely ablated at a 1% oxygen level in Hela and MRC5 cell lines. ADPM06 displays only a partial reduction in light-induced activity in hypoxic as compared to normoxic conditions. ADPM06-PDT induces ER stress and unfolded protein response. ADPM06-PDT induces apoptosis and involves caspase enzymatic activity. Following ADPM06-PDT, a rapid processing of XBP1 mRNA occurs resulting in the removal of an intron from the mRNA in a spliceosome-independent manner, a post-transcriptional modification catalyzed by the action of activated inositol-requiring protein 1 (IRE1). ADPM06-PDT-induced apoptosis involves the generation of ROS.
In Vivo:
ADPM06-PDT has revealed an initiation of apoptosis in vivo, as well as induction of an ER stress response. ADPM06-PDT is well tolerated in vivo and elicits impressive complete response rates in various models of cancer when a short drug-light interval is applied.
Products are for research use only. Not for human use.
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