DHODH-IN-1


Catalog No. Size PriceQuantity
M33082-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway.

Product information

CAS Number: 1800296-63-2

Molecular Weight: 403.40

Formula: C21H20F3N3O2

Chemical Name: 5-cyclopropyl-2-[4-(2,6-difluorophenoxy)-5-methyl-3-(propan-2-yloxy)-1H-pyrazol-1-yl]-3-fluoropyridine

Smiles: CC1=C(OC2C(F)=CC=CC=2F)C(=NN1C1=NC=C(C=C1F)C1CC1)OC(C)C

InChiKey: JNAABFZPXJJMPX-UHFFFAOYSA-N

InChi: InChI=1S/C21H20F3N3O2/c1-11(2)28-21-18(29-19-15(22)5-4-6-16(19)23)12(3)27(26-21)20-17(24)9-14(10-25-20)13-7-8-13/h4-6,9-11,13H,7-8H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DHODH-IN-1 (compound 18d) strongly inhibits Jurkat cells proliferation (IC50=0.02 μM). DHODH-IN-1 (4, 20, 100 nM) blocks the measles virus replication in cells. DHODH-IN-1 (0.008, 0.04, 0.2, 1, 5 μM) increases the expression of an ISRE-luciferase reporter gene when transfecting cells with ssRNA molecules.

In Vivo:

DHODH-IN-1 (compound 18d) has a t1/2 of 27–41 min.

Products are for research use only. Not for human use.

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