Description
PDE5-IN-2 is a potent, highly selective, and orally active PDE5 inhibitor, with an IC50 of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC50s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity.
Product information
CAS Number: 2244517-61-9
Molecular Weight: 491.52
Formula: C25H21N3O6S
Chemical Name: 3-[(2H-1,3-benzodioxol-5-yl)methyl]-8-hydroxy-6-[(2-methoxyethyl)amino]-1-(1,3-thiazol-2-yl)-2H,9H-chromeno[2,3-c]pyrrol-9-one
Smiles: COCCNC1=CC(O)=C2C(=O)C3=C(NC(CC4=CC5OCOC=5C=C4)=C3OC2=C1)C1=NC=CS1
InChiKey: VNWKVRSLWCIUCC-UHFFFAOYSA-N
InChi: InChI=1S/C25H21N3O6S/c1-31-6-4-26-14-10-16(29)20-19(11-14)34-24-15(8-13-2-3-17-18(9-13)33-12-32-17)28-22(21(24)23(20)30)25-27-5-7-35-25/h2-3,5,7,9-11,26,28-29H,4,6,8,12H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PDE5-IN-2 (Compound 3) has at least 1000-fold selectivity over PDE1B, PDE3A, PDE7A1, PDE8A1, and PDE9A2 (IC50s, >32 000 nM).
In Vivo:
PDE5-IN-2 (1.25 mg/kg, p.o.) shows anti-pulmonary arterial hypertension activity, decreases mean pulmonary artery pressure in rats.
Products are for research use only. Not for human use.
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