PDE5-IN-2


Catalog No. Size PriceQuantity
M33106-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

PDE5-IN-2 is a potent, highly selective, and orally active PDE5 inhibitor, with an IC50 of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC50s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity.

Product information

CAS Number: 2244517-61-9

Molecular Weight: 491.52

Formula: C25H21N3O6S

Chemical Name: 3-[(2H-1,3-benzodioxol-5-yl)methyl]-8-hydroxy-6-[(2-methoxyethyl)amino]-1-(1,3-thiazol-2-yl)-2H,9H-chromeno[2,3-c]pyrrol-9-one

Smiles: COCCNC1=CC(O)=C2C(=O)C3=C(NC(CC4=CC5OCOC=5C=C4)=C3OC2=C1)C1=NC=CS1

InChiKey: VNWKVRSLWCIUCC-UHFFFAOYSA-N

InChi: InChI=1S/C25H21N3O6S/c1-31-6-4-26-14-10-16(29)20-19(11-14)34-24-15(8-13-2-3-17-18(9-13)33-12-32-17)28-22(21(24)23(20)30)25-27-5-7-35-25/h2-3,5,7,9-11,26,28-29H,4,6,8,12H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PDE5-IN-2 (Compound 3) has at least 1000-fold selectivity over PDE1B, PDE3A, PDE7A1, PDE8A1, and PDE9A2 (IC50s, >32 000 nM).

In Vivo:

PDE5-IN-2 (1.25 mg/kg, p.o.) shows anti-pulmonary arterial hypertension activity, decreases mean pulmonary artery pressure in rats.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

You may also like

Recently viewed