T-2513


Catalog No. Size PriceQuantity
M33117-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death.

Product information

CAS Number: 288247-87-0

Molecular Weight: 449.50

Formula: C25H27N3O5

Chemical Name: (19S)-7-(3-aminopropoxy)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

Smiles: CC[C@]1(O)C2C=C3C4=NC5=CC=C(C=C5C(CC)=C4CN3C(=O)C=2COC1=O)OCCCN

InChiKey: XZLHHOGJQUVONU-VWLOTQADSA-N

InChi: InChI=1S/C25H27N3O5/c1-3-15-16-10-14(32-9-5-8-26)6-7-20(16)27-22-17(15)12-28-21(22)11-19-18(23(28)29)13-33-24(30)25(19,31)4-2/h6-7,10-11,31H,3-5,8-9,12-13,26H2,1-2H3/t25-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SN-38 is the metabolite of T-2513. T-2513 has a broad cytotoxicity against a range of human tumor cell lines.

In Vivo:

T-2513 (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma.

Products are for research use only. Not for human use.

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