Description
T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death.
Product information
CAS Number: 288247-87-0
Molecular Weight: 449.50
Formula: C25H27N3O5
Chemical Name: (19S)-7-(3-aminopropoxy)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
Smiles: CC[C@]1(O)C2C=C3C4=NC5=CC=C(C=C5C(CC)=C4CN3C(=O)C=2COC1=O)OCCCN
InChiKey: XZLHHOGJQUVONU-VWLOTQADSA-N
InChi: InChI=1S/C25H27N3O5/c1-3-15-16-10-14(32-9-5-8-26)6-7-20(16)27-22-17(15)12-28-21(22)11-19-18(23(28)29)13-33-24(30)25(19,31)4-2/h6-7,10-11,31H,3-5,8-9,12-13,26H2,1-2H3/t25-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SN-38 is the metabolite of T-2513. T-2513 has a broad cytotoxicity against a range of human tumor cell lines.
In Vivo:
T-2513 (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma.
Products are for research use only. Not for human use.
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