SW-100


Catalog No. Size PriceQuantity
M33125-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier.

Product information

CAS Number: 2126744-35-0

Molecular Weight: 316.78

Formula: C17H17ClN2O2

Chemical Name: 4-[(6-chloro-1,2,3,4-tetrahydroquinolin-1-yl)methyl]-N-hydroxybenzamide

Smiles: ONC(=O)C1C=CC(CN2CCCC3=CC(Cl)=CC=C23)=CC=1

InChiKey: MNAYBFFSFQRSIT-UHFFFAOYSA-N

InChi: InChI=1S/C17H17ClN2O2/c18-15-7-8-16-14(10-15)2-1-9-20(16)11-12-3-5-13(6-4-12)17(21)19-22/h3-8,10,22H,1-2,9,11H2,(H,19,21)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 125 mg/mL (394.60 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SW-100 (0.01-10 µM; 48 hours) shows obvious increase in the acetylated α-tubulin levels in a dose-dependent manner.

In Vivo:

SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome.

Products are for research use only. Not for human use.

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