Description
Tilianin is an active flavonoid glycoside found in many medical plants, with potential anti-hypertensive, myocardial-protective, anti-diabetic, anti-hyperlipidemic, anti-inflammatory and antioxidant effects.
Product information
CAS Number: 4291-60-5
Molecular Weight: 446.40
Formula: C22H22O10
Chemical Name: 5-hydroxy-2-(4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one
Smiles: COC1C=CC(=CC=1)C1=CC(=O)C2=C(C=C(C=C2O)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)O1
InChiKey: NLZCOTZRUWYPTP-MIUGBVLSSA-N
InChi: InChI=1S/C22H22O10/c1-29-11-4-2-10(3-5-11)15-8-14(25)18-13(24)6-12(7-16(18)31-15)30-22-21(28)20(27)19(26)17(9-23)32-22/h2-8,17,19-24,26-28H,9H2,1H3/t17-,19-,20+,21-,22-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 50 mg/mL (112.01 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Tilianin (10 μM, 20 μM) reduced secretion of LPS (1 μg/mL)-induced proinflammatory cytokine in RAW264.7 macrophage cell.
In Vivo:
Tilianin (10 mg/kg; i.p.) is a potential agent for ameliorating LPS-induced acute lung injury (ALI). Tilianin shows Tmax=10.8 min, Cmax=176.9 nmol/L, AUC0-∞= 17.4 min*μmol/L in mice.
Products are for research use only. Not for human use.
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