Description
Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain.
Product information
CAS Number: 88416-50-6
Molecular Weight: 360.92
Formula: CH10Cl2Na2O10P2
Chemical Name: disodium tetrahydrate hydrogen [dichloro(hydrogen phosphonato)methyl]phosphonate
Smiles: O.O.O.O.[Na+].[Na+].[O-]P(O)(=O)C(Cl)(Cl)P([O-])(O)=O
InChiKey: XWHPUCFOTRBMGS-UHFFFAOYSA-L
InChi: InChI=1S/CH4Cl2O6P2.2Na.4H2O/c2-1(3,10(4,5)6)11(7,8)9;;;;;;/h(H2,4,5,6)(H2,7,8,9);;;4*1H2/q;2*+1;;;;/p-2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: H2O : 125 mg/mL (344.42 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Clodronate disodium tetrahydrate, a first-generation bisphosphonate, significantly attenuates neuropathic and inflammatory pain unrelated to bone abnormalities via inhibition of VNUT, a key molecule for the initiation of purinergic chemical transmission . Clodronate disodium tetrahydrate is an allosteric modulator of VNUT Cl- dependence . Clodronate disodium tetrahydrate acts as antiresorptive in osteoporosis.
In Vivo:
Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition. Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition .
Products are for research use only. Not for human use.
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