AZD5718


Catalog No. Size PriceQuantity
M33208-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

AZD5718 is an orally active inhibitor of FLAP (5‑Lipoxygenase activating protein), with an IC50 of 2 nM. AZD5718 is used in the study for coronary artery disease.

Product information

CAS Number: 2041075-86-7

Molecular Weight: 446.50

Formula: C24H26N6O3

Chemical Name: (1R,2R)-2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-{4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-3-yl}cyclohexane-1-carboxamide

Smiles: CC1=CC(=NN1)C1C=CC(=CC=1)C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1C=NN2CCNC(=O)C2=1

InChiKey: ROTWSDMXHVGAHZ-QZTJIDSGSA-N

InChi: InChI=1S/C24H26N6O3/c1-14-12-19(29-28-14)15-6-8-16(9-7-15)22(31)17-4-2-3-5-18(17)23(32)27-20-13-26-30-11-10-25-24(33)21(20)30/h6-9,12-13,17-18H,2-5,10-11H2,1H3,(H,25,33)(H,27,32)(H,28,29)/t17-,18-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (279.96 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

AZD5718 demonstrates a dose dependent and greater than 90% suppression of leukotriene production over 24 h. AZD5718 exhibits an IC50 of 39 nM for LTB4.

In Vivo:

AZD5718 exhibits t1/2 of 0.45 h and 2.1 h in rat and dog by iv injection, respectively.

Products are for research use only. Not for human use.

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