Description
FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties.
Product information
CAS Number: 283167-06-6
Molecular Weight: 264.30
Formula: C14H17FN2O2
Chemical Name: N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide
Smiles: CC(=O)N1CCC(CC1)NC(=O)C1=CC=C(F)C=C1
InChiKey: VBHVOHJOTMCSBQ-UHFFFAOYSA-N
InChi: InChI=1S/C14H17FN2O2/c1-10(18)17-8-6-13(7-9-17)16-14(19)11-2-4-12(15)5-3-11/h2-5,13H,6-9H2,1H3,(H,16,19)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (945.89 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
FK962 (1 nM-1 μM) significantly enhances high K+-evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp.
In Vivo:
FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease.
Products are for research use only. Not for human use.
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