Acivicin hydrochloride


Catalog No. Size PriceQuantity
M33269-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.

Product information

CAS Number: 161922-40-3

Molecular Weight: 215.03

Formula: C5H8Cl2N2O3

Chemical Name: (2S)-2-amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid hydrochloride

Smiles: Cl.N[C@@H]([C@@H]1CC(Cl)=NO1)C(O)=O

InChiKey: IXBPTDHBIYEQHX-QYEIVYHBSA-N

InChi: InChI=1S/C5H7ClN2O3.ClH/c6-3-1-2(11-8-3)4(7)5(9)10;/h2,4H,1,7H2,(H,9,10);1H/t2-,4-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days) has an IC50 of 0.7 μM in human HepG2 cells.

In Vivo:

Acivicin hydrochloride (AT-125 hydrochloride; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%.

Products are for research use only. Not for human use.

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