Mal-amido-(CH2COOH)2


Catalog No. Size PriceQuantity
M33287-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker.

Product information

CAS Number: 207613-14-7

Molecular Weight: 284.22

Formula: C11H12N2O7

Chemical Name: 2-[N-(carboxymethyl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]acetic acid

Smiles: OC(=O)CN(CC(O)=O)C(=O)CCN1C(=O)C=CC1=O

InChiKey: WGKBLBPWMDGTDE-UHFFFAOYSA-N

InChi: InChI=1S/C11H12N2O7/c14-7(12(5-10(17)18)6-11(19)20)3-4-13-8(15)1-2-9(13)16/h1-2H,3-6H2,(H,17,18)(H,19,20)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates.

In Vivo:

ADC Linker

Products are for research use only. Not for human use.

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