Description
Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker.
Product information
CAS Number: 207613-14-7
Molecular Weight: 284.22
Formula: C11H12N2O7
Chemical Name: 2-[N-(carboxymethyl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]acetic acid
Smiles: OC(=O)CN(CC(O)=O)C(=O)CCN1C(=O)C=CC1=O
InChiKey: WGKBLBPWMDGTDE-UHFFFAOYSA-N
InChi: InChI=1S/C11H12N2O7/c14-7(12(5-10(17)18)6-11(19)20)3-4-13-8(15)1-2-9(13)16/h1-2H,3-6H2,(H,17,18)(H,19,20)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates.
In Vivo:
ADC Linker
Products are for research use only. Not for human use.
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