Description
Lp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.
Product information
CAS Number: 2071636-15-0
Molecular Weight: 394.46
Formula: C19H23FN2O4S
Chemical Name: 2-fluoro-5-{2-[(4S)-4-(4-methyl-1,1-dioxo-1λ⁶-thian-4-yl)-2-oxopyrrolidin-1-yl]ethoxy}benzonitrile
Smiles: CC1(CCS(=O)(=O)CC1)[C@@H]1CC(=O)N(C1)CCOC1=CC(C#N)=C(F)C=C1
InChiKey: SYEMWCXBADSSGE-OAHLLOKOSA-N
InChi: InChI=1S/C19H23FN2O4S/c1-19(4-8-27(24,25)9-5-19)15-11-18(23)22(13-15)6-7-26-16-2-3-17(20)14(10-16)12-21/h2-3,10,15H,4-9,11,13H2,1H3/t15-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Lp-PLA2-IN-2 inhibits Human Lp-PLA2 with an IC50 of 62 nM in PED6 assay.
In Vivo:
Lp-PLA2-IN-2 (1 mg/kg; i.v.) treament in rats shows that the Cl, Vss and t1/2 values are 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively.
Products are for research use only. Not for human use.
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