Hypromellose

Hypromellose is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices.

Product information

CAS Number: 9004-65-3

Molecular Weight: 748.81

Formula: C32H60O19

Chemical Name: 2-[(6-{[4,5-bis(2-hydroxypropoxy)-2-[(2-hydroxypropoxy)methyl]-6-methoxyoxan-3-yl]oxy}-4,5-dimethoxy-2-(methoxymethyl)oxan-3-yl)oxy]-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol

Smiles: COCC1OC(OC2C(OCC(C)O)C(OCC(C)O)C(OC2COCC(C)O)OC)C(OC)C(OC)C1OC1OC(CO)C(OC)C(O)C1O

InChiKey: VUKAUDKDFVSVFT-UHFFFAOYSA-N

InChi: InChI=1S/C32H60O19/c1-15(34)10-44-14-20-25(27(45-11-16(2)35)29(31(43-8)48-20)46-12-17(3)36)51-32-28(42-7)26(41-6)24(19(49-32)13-39-4)50-30-22(38)21(37)23(40-5)18(9-33)47-30/h15-38H,9-14H2,1-8H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 25 mg/mL (Need ultrasonic). H2O : 10 mg/mL (Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect. Hypromellose (hydroxypropylmethylcellulose) has been used in sustained-release pharmaceutical products for many years. When used in matrix tablets, these polymers hydrate on contact with water to produce a viscous gel barrier within and surrounding the tablet. The properties of hypromellose that affect the rate of drug release include the rate of diffusion of water into the dry polymer, the rate of hypromellose hydration and gel formation, the viscosity of the hydrated hypromellose and rate of hypromellose gel erosion.

In Vivo:

Punctal occlusion using hypromellose 2% is a low-cost and safe additional treatment for dry eye. Fluorescein and rose bengal staining tests show that there was a significant reduction in signs after occlusion using hypromellose. Hypromellose is effective in improving the blood glucose metabolism and suppressing oxidative stress in mice fed with a high fat diet. The antihyperglycemic and antioxidative effects of hypromellose could be partly attributed to the regulation of hepatic glucose-regulating enzyme activities and activation of the hepatic and erythrocyte antioxidant enzymes. Hypromellose may be useful as biomaterials in the development of functional food or as therapeutic agents against high fat-induced hyperglycemia and oxidative stress.

Products are for research use only. Not for human use.