COH34


Catalog No. Size PriceQuantity
M33363-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors.

Product information

CAS Number: 906439-72-3

Molecular Weight: 293.38

Formula: C18H15NOS

Chemical Name: 1-[(1E)-{[(4-methylphenyl)sulfanyl]imino}methyl]naphthalen-2-ol

Smiles: CC1C=CC(=CC=1)S/N=C/C1=C(O)C=CC2=CC=CC=C21

InChiKey: SFUAIBHPGDRCFL-XDHOZWIPSA-N

InChi: InChI=1S/C18H15NOS/c1-13-6-9-15(10-7-13)21-19-12-17-16-5-3-2-4-14(16)8-11-18(17)20/h2-12,20H,1H3/b19-12+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 16.67 mg/mL (56.82 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

COH34 efficiently kills PARP inhibitor-resistant cancer cells.

In Vivo:

COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models.

Products are for research use only. Not for human use.

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