Description
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors.
Product information
CAS Number: 906439-72-3
Molecular Weight: 293.38
Formula: C18H15NOS
Chemical Name: 1-[(1E)-{[(4-methylphenyl)sulfanyl]imino}methyl]naphthalen-2-ol
Smiles: CC1C=CC(=CC=1)S/N=C/C1=C(O)C=CC2=CC=CC=C21
InChiKey: SFUAIBHPGDRCFL-XDHOZWIPSA-N
InChi: InChI=1S/C18H15NOS/c1-13-6-9-15(10-7-13)21-19-12-17-16-5-3-2-4-14(16)8-11-18(17)20/h2-12,20H,1H3/b19-12+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 16.67 mg/mL (56.82 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
COH34 efficiently kills PARP inhibitor-resistant cancer cells.
In Vivo:
COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models.
Products are for research use only. Not for human use.
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