nor-NOHA HCl


Catalog No. Size PriceQuantity
M33390-2 2 mg solid $90
M33390-10 10 mg solid $220
M33390-100 100 mg solid $1,315

Description

nor-NOHA, also known as N-Hydroxy-nor-L-Arginine, is an Arginase inhibitor. nor-NOHA induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. Nor-NOHA can induce cell apoptosis and inhibit the ability of invasion and migration of HepG2 cells by inhibiting Arg1, which is related with the increase of iNOS expression and the high concentration of NO.

Product information

CAS Number: 291758-32-2

Molecular Weight: 249.10

Formula: C5H14Cl2N4O3

Chemical Name: (2S)-2-amino-4-[(E)-N''-hydroxycarbamimidamido]butanoic acid dihydrochloride

Smiles: Cl.Cl.N/C(/NCC[C@H](N)C(O)=O)=N\O

InChiKey: AKPIIXWPTMFQQJ-QTNFYWBSSA-N

InChi: InChI=1S/C5H12N4O3.2ClH/c6-3(4(10)11)1-2-8-5(7)9-12;;/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9);2*1H/t3-;;/m0../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Azambuja JH, Ludwig N, Yerneni SS, Braganhol E, Whiteside TL. Arginase-1+ Exosomes from Reprogrammed Macrophages Promote Glioblastoma Progression. Int J Mol Sci. 2020 Jun 2;21(11):3990. doi: 10.3390/ijms21113990. PMID: 32498400; PMCID: PMC7312363.
  2. Hannemann J, Roskam TI, Eilermann I, Siques P, Brito J, Böger R. Pre- Analytical and Clinical Validation of a Dried Blood Spot Assay for Asymmetric Dimethylarginine and L-Arginine. J Clin Med. 2020 Apr 9;9(4):1072. doi: 10.3390/jcm9041072. PMID: 32283799; PMCID: PMC7230730.

Products are for research use only. Not for human use.

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