Description
PARPYnD is a potent photoaffinity probe for poly(ADP-ribose) polymerase (PARP) (IC50 values for PARP2, PARP1 and PARP6 are 6, 38 and 230 nM, respectively). PARPYnD labels PARP1 and PARP2 in the cell when an N3 functionalized fluorescent probe is attached and can inhibit isolated PARP6.
Product information
CAS Number: 2561483-27-8
Molecular Weight: 613.67
Formula: C34H31N9O3
Synonym:
PARPYnD
PARPY nD
Chemical Name: 3-[3-(but-3-yn-1-yl)-3H-diazirin-3-yl]-N-[5-cyano-6-(4-{3-[(4-oxo-3, 4-dihydrophthalazin-1-yl)methyl]benzoyl}piperazin-1-yl)pyridin-3-yl]propanamide
Smiles: C#CCCC1(CCC(=O)NC2=CN=C(C(=C2)C#N)N2CCN(CC2)C(=O)C2=CC(CC3=NNC(=O)C4=CC=CC=C43)=CC=C2)N=N1
InChiKey: ZYWZRMXOMDKHKX-UHFFFAOYSA-N
InChi: InChI=1S/C34H31N9O3/c1-2-3-12-34(40-41-34)13-11-30(44)37-26-20-25(21-35)31(36-22-26)42-14-16-43(17-15-42)33(46)24-8-6-7-23(18-24)19-29-27-9-4-5-10-28(27)32(45)39-38-29/h1,4-10,18,20,22H,3,11-17,19H2,(H,37,44)(H,39,45)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Howard RT, Hemsley P, Petteruti P, Saunders CN, Molina Bermejo JA, Scott JS, Johannes JW, Tate EW. Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10. PMID: 32017532; PMCID: PMC7146755.
Products are for research use only. Not for human use.
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