SEN 177


Catalog No. Size PriceQuantity
M33403-2 2 mg solid $160
M33403-10 10 mg solid $450
M33403-C Contact sales@xcessbio.com for quotation $100

Description

SEN177 is an inhibitor of glutaminyl cyclase (QPCT), thereby rescuing the Huntington's disease (HD)-related phenotypes in cell.

Product information

CAS Number: 2117405-13-5

Molecular Weight: 338.38

Formula: C18H19FN6

Synonym:

SEN-177

SEN 177

Chemical Name: 6'-fluoro-2-[4-(4-methyl-4H-1, 2, 4-triazol-3-yl)piperidin-1-yl]-3, 3'-bipyridine

Smiles: CN1C=NN=C1C1CCN(CC1)C1=NC=CC=C1C1=CN=C(F)C=C1

InChiKey: AJIAMIPUWJQSPR-UHFFFAOYSA-N

InChi: InChI=1S/C18H19FN6/c1-24-12-22-23-17(24)13-6-9-25(10-7-13)18-15(3-2-8-20-18)14-4-5-16(19)21-11-14/h2-5,8,11-13H,6-7,9-10H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Pozzi C, Di Pisa F, Benvenuti M, Mangani S. The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders. J Biol Inorg Chem. 2018 Dec;23(8):1219-1226. doi: 10.1007/s00775-018-1605-1. Epub 2018 Aug 21. PubMed PMID: 30132075.

Products are for research use only. Not for human use.

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