Description
(Rac)-5-Hydroxymethyl Tolterodine ((Rac) -desFesoterodine) hydrochloride is the active metabolite of Tolterodine, It is a mAChR antagonist (Ki values of M1, M2, M3, M4 and M5 receptors are 2.3 nM, 2 nM, 2.5 nM, 2.8 nM and 2.9 nM, respectively). (Rac) -5-hydroxymethyl Tolterodine hydrochloride is used in the study of bladder hyperactivity.
Product information
CAS Number: 250214-40-5
Molecular Weight: 377.95
Formula: C22H32ClNO2
Chemical Name: 2-[3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenol;hydrochloride
Smiles: Cl.CC(C)N(CCC(C1=CC(CO)=CC=C1O)C1C=CC=CC=1)C(C)C
InChiKey: YCJSMQLBWOHICX-UHFFFAOYSA-N
InChi: InChI=1S/C22H31NO2.ClH/c1-16(2)23(17(3)4)13-12-20(19-8-6-5-7-9-19)21-14-18(15-24)10-11-22(21)25;/h5-11,14,16-17,20,24-25H,12-13,15H2,1-4H3;1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
In vitro, (Rac)-5-Hydroxymethyl Tolterodine (PNU-200577) hydrochloride produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips (KB of 0.84 nM; pA2 of 9.14)[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo:
(Rac)-5-Hydroxymethyl Tolterodine (5-HMT; 0.88 μmol/kg; i.v.) hydrochloride treatment shows the binding activity of (Rac)-5-Hydroxymethyl Tolterodine hydrochloride to muscarinic receptors is significantly observed in all tissues, except cerebral cortex, with a longer duration in bladder[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References:
Products are for research use only. Not for human use.
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