Description
pdTp is a highly selective, small molecule inhibitor of the miRNA regulatory complex RISC subunit SND1.
Product information
CAS Number: 2863-04-9
Molecular Weight: 402.19
Formula: C10H16N2O11P2
Synonym:
pdTp
Thymidine 3',5'-biphosphate
Chemical Name: {[(2R, 3S, 5R)-5-(5-methyl-2, 4-dioxo-1, 2, 3, 4-tetrahydropyrimidin-1-yl)-2-[(phosphonooxy)methyl]oxolan-3-yl]oxy}phosphonic acid
Smiles: CC1=CN([C@H]2C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O2)C(=O)NC1=O
InChiKey: CSNCBOPUCJOHLS-XLPZGREQSA-N
InChi: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(14)11-9(5)13)8-2-6(23-25(18,19)20)7(22-8)4-21-24(15,16)17/h3,6-8H,2,4H2,1H3,(H,11,13,14)(H2,15,16,17)(H2,18,19,20)/t6-,7+,8+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Loll PJ, Quirk S, Lattman EE, Garavito RM. X-ray crystal structures of staphylococcal nuclease complexed with the competitive inhibitor cobalt(II) and nucleotide. Biochemistry. 1995 Apr 4;34(13):4316-24. PubMed PMID: 7703245.
- Gschwentner M, Jungwirth A, Hofer S, Wöll E, Ritter M, Susanna A, Schmarda A, Reibnegger G, Pinggera GM, Leitinger M, Frick J, Deetjen P, Paulmichl M. Blockade of swelling-induced chloride channels by phenol derivatives. Br J Pharmacol. 1996 May;118(1):41-8. PubMed PMID: 8733574; PubMed Central PMCID: PMC1909500.
- Ulloa RM, Muschietti JP, Veron M, Torres HN, Tellez-Iñón MT. Purification and characterization of a soluble nucleoside diphosphate kinase in Trypanosoma cruzi. Mol Biochem Parasitol. 1995 Mar;70(1-2):119-29. PubMed PMID: 7637692.
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