Peptide 78

Peptide 78 identical to peptide 74 except that serine replaces cysteine; does not inhibit 72-kDa type IV collagenase. Peptide 78, a chemotactic cytokine, a 78 amino acid protein member of the IL-8 or C-X-C chemokine supergene family. ENA-78 plays an important role in the elicitation of predominantly neutrophils (PMNs) into the joints of rheumatoid arthritis (RA)

Product information

CAS Number: 132116-62-2

Molecular Weight: 1487.68

Formula: C60H106N22O20S

Chemical Name: (3S)-3-{[(2S)-1-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S, 3R)-2-amino-3-hydroxybutanamido]-4-(methylsulfanyl)butanamido]-5-carbamimidamidopentanamido]hexanamido]-5-carbamimidamidopentanamido]-3-hydroxypropanamido]acetamido}-3-carbamoylpropanoyl]pyrrolidin-2-yl]formamido}-3-{[(1S)-1-{[(1S)-1-{[(1S)-2-carbamoyl-1-carboxyethyl](propyl)carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}propanoic acid

Smiles: CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N(CCC)[C@@H](CC(N)=O)C(O)=O

InChiKey: OPKCDFWAZKOPFX-OMBAYSRHSA-N

InChi: InChI=1S/C60H106N22O20S/c1-7-21-81(40(58(101)102)26-42(63)86)56(99)30(4)72-55(98)46(29(2)3)80-52(95)36(25-44(88)89)78-53(96)39-16-12-22-82(39)57(100)37(24-41(62)85)73-43(87)27-71-47(90)38(28-83)79-50(93)34(15-11-20-70-60(67)68)75-48(91)32(13-8-9-18-61)74-49(92)33(14-10-19-69-59(65)66)76-51(94)35(17-23-103-6)77-54(97)45(64)31(5)84/h29-40,45-46,83-84H,7-28,61,64H2,1-6H3,(H2,62,85)(H2,63,86)(H,71,90)(H,72,98)(H,73,87)(H,74,92)(H,75,91)(H,76,94)(H,77,97)(H,78,96)(H,79,93)(H,80,95)(H,88,89)(H,101,102)(H4,65,66,69)(H4,67,68,70)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,45-,46-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Peptide 78 identical to peptide 74 except that serine replaces cysteine; does not inhibit 72-kDa type IV collagenase.

References:

1. Li Z, Wang Z, Zhang C, Chen J, Su Y, Huang J, Yi Z, Yuan C, Hong W, Wang Y, Wu Z, Hu Y, Cao L, Peng D, Guan Y, Zou Y, Yu S, Cui D, Fang Y. Reduced ENA78 levels as novel biomarker for major depressive disorder and venlafaxine efficiency: Result from a prospective longitudinal study. Psychoneuroendocrinology. 2017 Jul;81:113-121. doi: 10.1016/j.psyneuen.2017.03.015. Epub 2017 Mar 18. PubMed PMID: 28441588.
2. Liu L, Chowdhury S, Fang X, Liu JL, Srikant CB. Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells. FEBS Lett. 2014 May 29;588(11):2016-24. doi: 10.1016/j.febslet.2014.04.030. Epub 2014 May 4. PubMed PMID: 24801175.

Products are for research use only. Not for human use.