Description
MK-4688 is a highly potent, selective, and low-molecular-weight inhibitor suitable for clinical investigation. MK-4688 is an efficient inhibitor of the HDM2-p53 protein-protein interaction.
Product information
CAS Number: 1616428-79-5
Molecular Weight: 550.05
Formula: C28H32ClN7O3
Smiles: C[C@@H]1CC[C@@H](CN2C3=C(N=C(C=C3N=C2N2CCO[C@@H]3CCC[C@@H]23)C2NC(=O)ON=2)C2=CC(Cl)=CN=C2)CC1
InChiKey: FDBWTMMKIZGUEZ-IEGYKGNPSA-N
InChi: InChI=1S/C28H32ClN7O3/c1-16-5-7-17(8-6-16)15-36-25-20(32-27(36)35-9-10-38-23-4-2-3-22(23)35)12-21(26-33-28(37)39-34-26)31-24(25)18-11-19(29)14-30-13-18/h11-14,16-17,22-23H,2-10,15H2,1H3,(H,33,34,37)/t16-,17-,22-,23-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Reutershan MH, Machacek MR, Altman MD, Bogen S, Cai M, Cammarano C, Chen D, Christopher M, Cryan J, Daublain P, Fradera X, Geda P, Goldenblatt P, Hill AD, Kemper RA, Kutilek V, Li C, Martinez M, McCoy M, Nair L, Pan W, Thompson CF, Scapin G, Shizuka M, Spatz ML, Steinhuebel D, Sun B, Voss ME, Wang X, Yang L, Yeh TC, Dussault I, Marshall CG, Trotter BW. Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction. J Med Chem. 2021 Oct 29. doi: 10.1021/acs.jmedchem.1c01524. Epub ahead of print. PMID: 34714078.
Products are for research use only. Not for human use.
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