Description
MMV666810 is a novel inhibitor of Plasmodium falciparum gametocytes. MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM).
Product information
CAS Number: 1450666-97-3
Molecular Weight: 442.43
Formula: C23H21F3N4O2
Chemical Name: 1-(4-{5-amino-6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}benzoyl)piperidin-4-ol
Smiles: NC1=NC=C(N=C1C1C=CC(=CC=1)C(F)(F)F)C1C=CC(=CC=1)C(=O)N1CCC(O)CC1
InChiKey: FKDIWALLMXDOBS-UHFFFAOYSA-N
InChi: InChI=1S/C23H21F3N4O2/c24-23(25,26)17-7-5-15(6-8-17)20-21(27)28-13-19(29-20)14-1-3-16(4-2-14)22(32)30-11-9-18(31)10-12-30/h1-8,13,18,31H,9-12H2,(H2,27,28)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Niemand J, et al. Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS Infect Dis. 2021 Oct 8;7(10):2904-2916.
Products are for research use only. Not for human use.
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