Description
TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites.
Product information
CAS Number: 872113-12-7
Molecular Weight: 399.83
Formula: C19H18ClN5O3
Chemical Name: N-(5-chloro-2-methoxyphenyl)-2-[N-methyl-1-(2-phenyl-2H-1, 2, 3-triazol-4-yl)formamido]acetamide
Smiles: CN(CC(=O)NC1=CC(Cl)=CC=C1OC)C(=O)C1C=NN(N=1)C1C=CC=CC=1
InChiKey: RHRZUZMCICRKJA-UHFFFAOYSA-N
InChi: InChI=1S/C19H18ClN5O3/c1-24(12-18(26)22-15-10-13(20)8-9-17(15)28-2)19(27)16-11-21-25(23-16)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3,(H,22,26)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Chia W, et al. High-Content Phenotypic Screen of a Focused TCAMS Drug Library Identifies Novel Disruptors of the Malaria Parasite Calcium Dynamics. ACS Chem Biol. 2021 Nov 19;16(11):2348-2372.
Products are for research use only. Not for human use.
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