Ispronicline


Catalog No. Size PriceQuantity
M33567-2 2 mg solid $90
M33567-10 10 mg solid $185
M33567-100 100 mg solid $1,070
M33567-C Contact sales@xcessbio.com for quotation $100

Description

Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity (Ki=11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR.

Product information

CAS Number: 252870-53-4

Molecular Weight: 234.34

Formula: C14H22N2O

Chemical Name: methyl[(2S, 4E)-5-[5-(propan-2-yloxy)pyridin-3-yl]pent-4-en-2-yl]amine

Smiles: CC(C)OC1=CN=CC(/C=C/C[C@H](C)NC)=C1

InChiKey: RPCVIAXDAUMJJP-PZBABLGHSA-N

InChi: InChI=1S/C14H22N2O/c1-11(2)17-14-8-13(9-16-10-14)7-5-6-12(3)15-4/h5,7-12,15H,6H2,1-4H3/b7-5+/t12-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Ispronicline (10-20 mg/kg; s.c.) induces c-Fos expression in selective regions of the rat forebrain. Ispronicline pharmacokinetics (half-life of 2 h in rats) contrasts with the long-lasting improvement of working memory (18 h to 2 d).

References:

  1. Julie Jacobsen, et al. The α4β2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain. Neurosci Lett. 2012 Apr 25;515(1):7-11.

Products are for research use only. Not for human use.

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