Description
Neoquassine is a CYP1A1 inhibitor isolated from Picrasma excelsa. Neoquassin is found in Picrasma quassioides.
Product information
CAS Number: 76-77-7
Molecular Weight: 390.47
Formula: C22H30O6
Chemical Name: (1S, 2S, 6S, 7S, 9R, 13R, 17S)-11-hydroxy-4, 15-dimethoxy-2, 6, 14, 17-tetramethyl-10-oxatetracyclo[7.7.1.0, .0, ]heptadeca-4, 14-diene-3, 16-dione
Smiles: CC1[C@@H]2CC(O)O[C@@H]3C[C@H]4[C@H](C)C=C(OC)C(=O)[C@]4(C)[C@@H](C(=O)C=1OC)[C@@]32C
InChiKey: BDQNCUODBJZKIY-NUPPOKJBSA-N
InChi: InChI=1S/C22H30O6/c1-10-7-14(26-5)20(25)22(4)12(10)8-15-21(3)13(9-16(23)28-15)11(2)18(27-6)17(24)19(21)22/h7,10,12-13,15-16,19,23H,8-9H2,1-6H3/t10-,12+,13+,15-,16?,19+,21-,22+/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Mishra K, Chakraborty D, Pal A, Dey N. Plasmodium falciparum: in vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin. Exp Parasitol. 2010 Apr;124(4):421-7. doi: 10.1016/j.exppara.2009.12.007. Epub 2009 Dec 29. PubMed PMID: 20036657.
- Lang'at-Thoruwa C, Kirby GC, Phillipson JD, Warhurst DC, Watt RA, Wright CW. Enhancement of the antiplasmodial activity of quassin by transformation into a gamma-lactone. J Nat Prod. 2003 Nov;66(11):1486-9. PubMed PMID: 14640524.
Products are for research use only. Not for human use.
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