Description
Exeporfinium, also known as XF-73, is an anti-microbial which works via weakening bacteria cell walls. Exeporfinium chloride is a potential treatment for methicillin-resistant Staphylococcus aureus (MRSA) and possibly Clostridium difficile. Exeporfinium chloride has completed a phase I clinical trial for nasal decolonisation of MRSA—being tested against 5 bacterial strains. It seems unlikely to cause MRSA to develop resistance to it. Structurally it is a dicationic porphyrin.
Product information
CAS Number: 718638-68-7
Molecular Weight: 765.81
Formula: C44H50Cl2N6O2
Synonym:
XF-73
XF 73
Chemical Name: 3, 3'-((porphyrin-5, 15-diylbis(4, 1-phenylene))bis(oxy))bis(N, N, N-trimethylpropan-1-aminium) chloride
Smiles: [Cl-].[Cl-].C[N+](C)(C)CCCOC1C=CC(=CC=1)C1C2=CC=C(C=C3C=CC(=N3)C(=C3C=CC(=CC4C=CC=1N=4)N3)C1C=CC(=CC=1)OCCC[N+](C)(C)C)N2
InChiKey: KJLHJQGDBJNMPU-XRFOENPRSA-L
InChi: InChI=1S/C44H50N6O2.2ClH/c1-49(2,3)25-7-27-51-37-17-9-31(10-18-37)43-39-21-13-33(45-39)29-35-15-23-41(47-35)44(42-24-16-36(48-42)30-34-14-22-40(43)46-34)32-11-19-38(20-12-32)52-28-8-26-50(4,5)6;;/h9-24,29-30,45,48H,7-8,25-28H2,1-6H3;2*1H/q+2;;/p-2/b33-29-,34-30-,35-29-,36-30-,43-39-,43-40-,44-41-,44-42-;;
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Walker K. Interscience Conference on Antimicrobial Agents and Chemotherapy - 50th Annual Meeting - Research on Promising New Agents: Part 1. IDrugs. 2010 Nov;13(11):743-5. PubMed PMID: 21046515.
- Gonzales FP, Felgenträger A, Bäumler W, Maisch T. Fungicidal photodynamic effect of a twofold positively charged porphyrin against Candida albicans planktonic cells and biofilms. Future Microbiol. 2013 Jun;8(6):785-97. doi: 10.2217/fmb.13.44. PubMed PMID: 23701333.
Products are for research use only. Not for human use.
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