Irloxacin

Irloxacin is a new quinolone derivative, and shows greater activity with an acid pH. It has a good in vitro antimicrobial spectrum against both gram-positive and gram-negative bacteria. In vitro activity of irloxacin against mycobacteria (20 M. tuberculosis, 17 M. avium, 5 Mycobacterium bovis, 5 Mycobacterium chelonae, 5 Mycobacterium fortuitum and 1 Mycobacterium gadium) using the Bactec at pH 6.8 and 5.0, with other quinolones (ofloxacin, ciprofloxacin, pefloxacin and 27753 RP) were compared. All quinolones tested showed good activity against mycobacteria at pH 6.8 and 5.0. Irloxacin at pH 5.0 had a greater activity against M. avium.

Product information

CAS Number: 91524-15-1

Molecular Weight: 300.28

Formula: C16H13FN2O3

Chemical Name: 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1H-pyrrol-1-yl)-

Smiles: CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(C=C12)N1C=CC=C1

InChiKey: RZLHGQLYNZQZQQ-UHFFFAOYSA-N

InChi: InChI=1S/C16H13FN2O3/c1-2-18-9-11(16(21)22)15(20)10-7-12(17)14(8-13(10)18)19-5-3-4-6-19/h3-9H,2H2,1H3,(H,21,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Yang M, Yang Y, Lei M, Ye C, Zhao C, Xu J, Wu K, Yu M. Experimental studies on soft contact lenses for controlled ocular delivery of pirfinedone: in vitro and in vivo. Drug Deliv. 2016 Nov;23(9):3538-3543. doi: 10.1080/10717544.2016.1204570. Epub 2016 Jul 17. PMID: 27331555.
2. Guerrini V, De Rosa M, Pasquini S, Mugnaini C, Brizzi A, Cuppone AM, Pozzi G, Corelli F. New fluoroquinolones active against fluoroquinolones-resistant Mycobacterium tuberculosis strains. Tuberculosis (Edinb). 2013 Jul;93(4):405-11. doi: 10.1016/j.tube.2013.02.017. Epub 2013 Mar 22. PMID: 23523640.
3. Guzmán A, García C, Marín AP, Willoughby C, Demestre I. Developmental toxicity studies of the quinolone antibacterial agent irloxacin in rats and rabbits. Arzneimittelforschung. 2003;53(2):121-5. doi: 10.1055/s-0031-1297082. PMID: 12642968.
4. Guzmán A, García C, Demestre I. Subchronic toxicity of the new quinolone antibacterial agent irloxacin in beagle dogs. Arzneimittelforschung. 2000 May;50(5):485-94. doi: 10.1055/s-0031-1300234. PMID: 10858877.

Products are for research use only. Not for human use.