Description
PD-159206 is a nucleocapsid inhibitor. It exhibits good antiviral activity against HIV. In T cell culture, the 50% inhibitory concentrations (EC(50)) of PD 161374 was on average 2.5 microM (ranges of 1.2-13.5 microM) without any cytotoxic effect up to 100 microM. PD 161374 inhibited acute HIV infection and it was effective when added during the early phase of HIV infection. PD 161374 exerts its antiviral effect at pre-integration steps in the early phase of the virus life cycle.
Product information
CAS Number: 171744-42-6
Molecular Weight: 532.67
Formula: C26H32N2O6S2
Chemical Name: N, N'-[Dithiobis(2, 1-phenylenecarbonyl)]bis[isoleucine]
Smiles: C[C@@H](CC)[C@H](NC(=O)C1=CC=CC=C1SSC1=CC=CC=C1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)C(O)=O
InChiKey: SUQDXZBTWJQATJ-QDGJQWLKSA-N
InChi: InChI=1S/C26H32N2O6S2/c1-5-15(3)21(25(31)32)27-23(29)17-11-7-9-13-19(17)35-36-20-14-10-8-12-18(20)24(30)28-22(26(33)34)16(4)6-2/h7-16,21-22H,5-6H2,1-4H3,(H,27,29)(H,28,30)(H,31,32)(H,33,34)/t15-,16-,21-,22-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Sharmeen L, McQuade T, Heldsinger A, Gogliotti R, Domagala J, Gracheck S. Inhibition of the early phase of HIV replication by an isothiazolone, PD 161374. Antiviral Res. 2001 Feb;49(2):101-14. doi: 10.1016/s0166-3542(00)00143-1. PMID: 11248362.
- Domagala JM, Gogliotti R, Sanchez JP, Stier MA, Musa K, Song Y, Loo J, Reily M, Tummino P, Harvey P, Hupe D, Sharmeen L, Mack D, Scholten J, Saunders J, McQuade T. 2,2'-Dithiobisbenzamides and 2-benzisothiazolones, two new classes of antiretroviral agents: SAR and mechanistic considerations. Drug Des Discov. 1997 May;15(1):49-61. PMID: 9332831.
Products are for research use only. Not for human use.
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