11-Dehydrocorticosterone

11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner. 11-Dehydrocorticosterone decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of 11β-hydroxysteroid dehydrogenase inhibition induced by carbenoxolone. Chronic administration 11-dehydrocorticosterone increases plasma glucocorticoids levels, body weight gain, and adiposity, as well as induces insulin resistance in mice.

Product information

CAS Number: 72-23-1

Molecular Weight: 344.44

Formula: C21H28O4

Chemical Name: (8S, 9S, 10R, 13S, 14S, 17S)-17-(2-hydroxyacetyl)-10, 13-dimethyl-1, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17-dodecahydro-3H-cyclopenta[a]phenanthrene-3, 11(2H)-dione

Smiles: C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@@H]2C(=O)CO

InChiKey: FUFLCEKSBBHCMO-KJQYFISQSA-N

InChi: InChI=1S/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-16,19,22H,3-8,10-11H2,1-2H3/t14-,15-,16+,19+,20-,21-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Siemienowicz KJ, Wang Y, Marečková M, Nio-Kobayashi J, Fowler PA, Rae MT, Duncan WC. Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses. Sci Rep. 2020 Dec 14;10(1):21920. doi: 10.1038/s41598-020-78976-x. PMID: 33318609; PMCID: PMC7736841.
2. Chu L, Liu W, Deng J, Wu Y, Yang H, Wang W, Hussain A, Li N, Zhou D, Deng H. Age-related changes in endogenous glucocorticoids, gonadal steroids, endocannabinoids and their ratios in plasma and hair from the male C57BL/6 mice. Gen Comp Endocrinol. 2020 Oct 26;301:113651. doi: 10.1016/j.ygcen.2020.113651. Epub ahead of print. PMID: 33122035.
3. Chen J, Mishra R, Yu Y, McDonald JG, Eckert KM, Gao L, Mendelson CR. Decreased 11β-hydroxysteroid dehydrogenase 1 in lungs of steroid receptor coactivator (Src)-1/-2 double-deficient fetal mice is caused by impaired glucocorticoid and cytokine signaling. FASEB J. 2020 Dec;34(12):16243-16261. doi: 10.1096/fj.202001809R. Epub 2020 Oct 18. PMID: 33070362; PMCID: PMC7713510.

Products are for research use only. Not for human use.