Description
ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor.
Product information
Molecular Weight: 763.28
Formula: C41H43ClN8O5
Smiles: CN([C@@H]1CC[C@H](CC1)NC(=O)C1C=CC(=CC=1)N1CCN(CC1)C1CN(C1)C1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O)C1=CC(Cl)=C(C=C1)C#N
InChiKey: LUCHABJUYSYJAT-RVWRWSNSSA-N
InChi: InChI=1S/C41H43ClN8O5/c1-46(30-9-4-26(22-43)35(42)21-30)28-10-5-27(6-11-28)44-38(52)25-2-7-29(8-3-25)47-16-18-48(19-17-47)32-23-49(24-32)31-12-13-33-34(20-31)41(55)50(40(33)54)36-14-15-37(51)45-39(36)53/h2-4,7-9,12-13,20-21,27-28,32,36H,5-6,10-11,14-19,23-24H2,1H3,(H,44,52)(H,45,51,53)/t27-,28-,36?
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Weiguo Xiang. et al. Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer. J Med Chem. 2021 Sep 23;64(18):13487-13509.
Products are for research use only. Not for human use.
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