Description
Thalidomide-5, 6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5, 6-F can be connected to the ligand for protein by a linker to form PROTACs.
Product information
CAS Number: 1496997-41-1
Molecular Weight: 294.21
Formula: C13H8F2N2O4
Smiles: O=C1CCC(C(=O)N1)N1C(=O)C2=CC(F)=C(F)C=C2C1=O
InChiKey: AGHXYRKTAZEQQW-UHFFFAOYSA-N
InChi: InChI=1S/C13H8F2N2O4/c14-7-3-5-6(4-8(7)15)13(21)17(12(5)20)9-1-2-10(18)16-11(9)19/h3-4,9H,1-2H2,(H,16,18,19)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Liu K, et al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013;11(29):4757-4763.
Products are for research use only. Not for human use.
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