Description
LDHA/PDKs-IN-1 (compound 20e) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 0.8 and 0.15 μM, respectively. LDHA/PDKs-IN-1 reduces A549 cell proliferation with an EC50 of 13.2 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-1 has the potential for the research of cancer diseases.
Product information
CAS Number: 2490699-40-4
Molecular Weight: 360.38
Formula: C19H21FN2O4
Smiles: CC1OC=CC(=O)C=1OCCN1CCN(CC1)C(=O)C1C=CC(F)=CC=1
InChiKey: AHYWOCBRZPCRAD-UHFFFAOYSA-N
InChi: InChI=1S/C19H21FN2O4/c1-14-18(17(23)6-12-25-14)26-13-11-21-7-9-22(10-8-21)19(24)15-2-4-16(20)5-3-15/h2-6,12H,7-11,13H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Xiang S, et al. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. Eur J Med Chem. 2020;203:112579.
Products are for research use only. Not for human use.
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