GSK199


Catalog No. Size PriceQuantity
M33938-C Contact sales@xcessbio.com for quotation $100

Description

GSK199 is a reversible and selective PAD4 inhibitor with an IC50 of 200 nM in the absence of calcium.

Product information

CAS Number: 1549811-53-1

Molecular Weight: 468.98

Formula: C24H29ClN6O2

Smiles: Cl.CN1C2C(=CC(=CC=2N=C1C1=CC2=CC=CN=C2N1CC)C(=O)N1C[C@H](N)CCC1)OC

InChiKey: KRGMIOKDGHBYQE-UNTBIKODSA-N

InChi: InChI=1S/C24H28N6O2.ClH/c1-4-30-19(12-15-7-5-9-26-22(15)30)23-27-18-11-16(13-20(32-3)21(18)28(23)2)24(31)29-10-6-8-17(25)14-29;/h5,7,9,11-13,17H,4,6,8,10,14,25H2,1-3H3;1H/t17-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Lewis HD, et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015 Mar;11(3):189-91.

Products are for research use only. Not for human use.

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