TRβ agonist 1


Catalog No. Size PriceQuantity
M33968-C Contact sales@xcessbio.com for quotation $100

Description

TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, with an EC50 value of 21 nM. TRβ agonist 1 can be used for researching dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH).

Product information

Molecular Weight: 548.52

Formula: C29H25FN2O8

Smiles: CC1C=C(C=C(C)C=1OC1=CC2=C(N=C(C(=O)NCC(O)=O)C(O)=C2C=C1)OC)C(=O)C1=CC(=CC(F)=C1)OC

InChiKey: CRBPLLHXFFMVKV-UHFFFAOYSA-N

InChi: InChI=1S/C29H25FN2O8/c1-14-7-16(25(35)17-9-18(30)11-20(10-17)38-3)8-15(2)27(14)40-19-5-6-21-22(12-19)29(39-4)32-24(26(21)36)28(37)31-13-23(33)34/h5-12,36H,13H2,1-4H3,(H,31,37)(H,33,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Li Q, et al. Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist. J Med Chem. 2022;65(10):7193-7211.

Products are for research use only. Not for human use.

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