Abecarnil

Abecarnil is a beta carboline and a partial benzodiazepine-receptor agonist that has demonstrated promise as an anxiolytic agent. It may be useful in treating generalized anxiety disorder.

Product information

CAS Number: 111841-85-1

Molecular Weight: 404.46

Formula: C24H24N2O4

Chemical Name: 6-(Benzyloxy)-4-(methoxymethyl)-9H-pyrido[3, 4-b]indole-3-carboxylic acid 1-methylethyl ester

Smiles: COCC1=C2C(=CN=C1C(=O)OC(C)C)NC1=CC=C(C=C12)OCC1C=CC=CC=1

InChiKey: RLFKILXOLJVUNF-UHFFFAOYSA-N

InChi: InChI=1S/C24H24N2O4/c1-15(2)30-24(27)23-19(14-28-3)22-18-11-17(29-13-16-7-5-4-6-8-16)9-10-20(18)26-21(22)12-25-23/h4-12,15,26H,13-14H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Pollack MH, Worthington JJ, Manfro GG, Otto MW, Zucker BG. Abecarnil for the treatment of generalized anxiety disorder: a placebo-controlled comparison of two dosage ranges of abecarnil and buspirone. J Clin Psychiatry. 1997;58 Suppl 11:19-23. PubMed PMID: 9363044.
2. Lydiard RB, Ballenger JC, Rickels K. A double-blind evaluation of the safety and efficacy of abecarnil, alprazolam, and placebo in outpatients with generalized anxiety disorder. Abecarnil Work Group. J Clin Psychiatry. 1997;58 Suppl 11:11-8. PubMed PMID: 9363043.
3. Turski L, Stephens DN, Jensen LH, Petersen EN, Meldrum BS, Patel S, Hansen JB, Löscher W, Schneider HH, Schmiechen R. Anticonvulsant action of the beta-carboline abecarnil: studies in rodents and baboon, Papio papio. J Pharmacol Exp Ther. 1990 Apr;253(1):344-52. PubMed PMID: 1970362.
4. Kasteleijn-Nolst Trenité DG, Groenwold RH, Schmidt B, Löscher W. Single dose efficacy evaluation of two partial benzodiazepine receptor agonists in photosensitive epilepsy patients: A placebo-controlled pilot study. Epilepsy Res. 2016 May;122:30-6. doi: 10.1016/j.eplepsyres.2016.02.003. Epub 2016 Feb 11. PubMed PMID: 26921854.
5. Rickels K, DeMartinis N, Aufdembrinke B. A double-blind, placebo-controlled trial of abecarnil and diazepam in the treatment of patients with generalized anxiety disorder. J Clin Psychopharmacol. 2000 Feb;20(1):12-8. PubMed PMID: 10653203.
6. Ozawa M, Nakada Y, Sugimachi K, Yabuuchi F, Akai T, Mizuta E, Kuno S, Yamaguchi M. Pharmacological characterization of the novel anxiolytic beta-carboline abecarnil in rodents and primates. Jpn J Pharmacol. 1994 Mar;64(3):179-87. PubMed PMID: 7912751.

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