Antimalarial agent 11


Catalog No. Size PriceQuantity
M34042-C Contact sales@xcessbio.com for quotation $100

Description

Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC50s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively[1].

Product information

CAS Number: 1214454-56-4

Molecular Weight: 425.47

Formula: C25H25F2NO3

Smiles: OC1CC2(CCN(CC(O)C3=CC(F)=C(F)C=C3)CC2)OC2C1=CC=C1C=CC=CC1=2

InChiKey: PILGVBYEWDKGIX-UHFFFAOYSA-N

InChi: InChI=1S/C25H25F2NO3/c26-20-8-6-17(13-21(20)27)23(30)15-28-11-9-25(10-12-28)14-22(29)19-7-5-16-3-1-2-4-18(16)24(19)31-25/h1-8,13,22-23,29-30H,9-12,14-15H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Iredia D Iyamu, et al. Structure-activity and structure-property relationship studies of spirocyclic chromanes with antimalarial activity. Bioorg Med Chem. 2022 Mar 1;57:116629.

Products are for research use only. Not for human use.

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