Description
pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC5o values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR. HER4. EGFR T790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities !!).
Product information
CAS Number: 1639040-94-0
Molecular Weight: 408.25
Formula: C19H14BrN5O
Smiles: C=CC(=O)NC1=CC2=C(NC3C=C4C(Br)=CNC4=CC=3)N=CN=C2C=C1
InChiKey: ATUXFPJRTSKHFB-UHFFFAOYSA-N
InChi: InChI=1S/C19H14BrN5O/c1-2-18(26)24-11-3-6-17-14(8-11)19(23-10-22-17)25-12-4-5-16-13(7-12)15(20)9-21-16/h2-10,21H,1H2,(H,24,26)(H,22,23,25)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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