MeIQx

MeIQx, also known as 8-Methyl-IQX, is a synthetic, pale orange to brown crystalline solid that is soluble in dimethylsulfoxide and methanol. It is produced in small quantities for research purposes. 2-Amino-3, 8-dimethylimidazo[4, 5-f]quinoxaline is formed naturally during the cooking of muscle-derived foods (meat and fish). Levels of this chemical produced in this manner are dependent on cooking temperature, cooking time and method of cooking (direct or indirect). It is one of the most abundant heterocyclic amines in a typical Western diet. 2-Amino-3, 8-dimethylimidazo[4, 5-f]quinoxaline has also been detected in processed food flavorings, beer, wine, and cigarette smoke. It is reasonably anticipated to be a human carcinogen.

Product information

CAS Number: 77500-04-0

Molecular Weight: 213.24

Formula: C11H11N5

Chemical Name: 3, 8-Dimethyl-3H-imidazo(4, 5-f)quinoxalin-2-amine

Smiles: CC1=CN=C2C=CC3=C(N=C(N)N3C)C2=N1

InChiKey: DVCCCQNKIYNAKB-UHFFFAOYSA-N

InChi: InChI=1S/C11H11N5/c1-6-5-13-7-3-4-8-10(9(7)14-6)15-11(12)16(8)2/h3-5H,1-2H3,(H2,12,15)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Jiang Y, Jiang Q, Fan D, Wang M, Zhao Y. Effect of Acrolein, a Lipid Oxidation Product, on the Formation of the Heterocyclic Aromatic Amine 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in Model Systems and Roast Salmon Patties. J Agric Food Chem. 2022 May 18;70(19):5887-5895. doi: 10.1021/acs.jafc.2c00970. Epub 2022 May 3. PMID: 35504016.
2. Kocaoğlu Cenkci S, Kaya B. Effects of Chlorophyll a and b in Reducing Genotoxicity of 2-Amino-3,8-dimethylimidazo[4,5-F]quinoxaline (MeIQx). Biology (Basel). 2022 Apr 15;11(4):602. doi: 10.3390/biology11040602. PMID: 35453801; PMCID: PMC9028374.
3. Hidalgo FJ, Lavado-Tena CM, Zamora R. Identification of acrolein as the reactive carbonyl responsible for the formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). Food Chem. 2021 May 1;343:128478. doi: 10.1016/j.foodchem.2020.128478. Epub 2020 Oct 27. PMID: 33158682.

Products are for research use only. Not for human use.