Description
MNK8 is a novel inhibitor of STAT3 activation, reducing DNA binding ability, increasing SubG1 cell population and inducing apoptosis in HCC cells.
Product information
CAS Number: 2055078-49-2
Molecular Weight: 252.27
Formula: C15H12N2O2
Chemical Name: 3-methyl-6-(naphthalen-1-yl)pyrimidine-2, 4(1H, 3H)-dione
Smiles: CN1C(=O)NC(=CC1=O)C1=CC=CC2=CC=CC=C21
InChiKey: SJRMGNRXVMMJSY-UHFFFAOYSA-N
InChi: InChI=1S/C15H12N2O2/c1-17-14(18)9-13(16-15(17)19)12-8-4-6-10-5-2-3-7-11(10)12/h2-9H,1H3,(H,16,19)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Sajith AM, Narasimhamurthy KH, Shanmugam MK, Rangappa S, Chandra Nayak S, Chinnathambi A, Awad Alahmadi T, Ali Alharbi S, Haridas KR, Reddy EK, Savitha B, Mohan CD, Rangappa KS. Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells. Bioorg Med Chem Lett. 2021 Oct 15;50:128332. doi: 10.1016/j.bmcl.2021.128332. Epub 2021 Aug 19. PMID: 34418571.
Products are for research use only. Not for human use.
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