YTX-465

YTX-465 is a SCD inhibitor. YTX-465 strongly reduced fatty desaturation in a concentration-dependent manner, with a 50% reduction in desaturation at 0.03 mM YTX-465

Product information

CAS Number: 2225824-53-1

Molecular Weight: 458.51

Formula: C25H26N6O3

Chemical Name: N-(2-(4-(3-(1, 3-dimethyl-1H-indazol-6-yl)-1, 2, 4-oxadiazol-5-yl)piperidin-1-yl)-2-oxoethyl)benzamide

Smiles: CN1N=C(C)C2=CC=C(C=C12)C1N=C(ON=1)C1CCN(CC1)C(=O)CNC(=O)C1C=CC=CC=1

InChiKey: UNYSKYOVUXWBJG-UHFFFAOYSA-N

InChi: InChI=1S/C25H26N6O3/c1-16-20-9-8-19(14-21(20)30(2)28-16)23-27-25(34-29-23)18-10-12-31(13-11-18)22(32)15-26-24(33)17-6-4-3-5-7-17/h3-9,14,18H,10-13,15H2,1-2H3,(H,26,33)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Vincent BM, Tardiff DF, Piotrowski JS, Aron R, Lucas MC, Chung CY, Bacherman H, Chen Y, Pires M, Subramaniam R, Doshi DB, Sadlish H, Raja WK, Solís EJ, Khurana V, Le Bourdonnec B, Scannevin RH, Rhodes KJ. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity. Cell Rep. 2018 Dec 4;25(10):2742-2754.e31. doi: 10.1016/j.celrep.2018.11.028. PMID: 30517862.

Products are for research use only. Not for human use.