Description
JNK-1-IN-4 (Compound E1) is an inhibitor for JNK, that inhibits JNK-1, JNK-2 and JNK-3 with IC50s of 2.7, 19.0 and 9.0 nM, respectively. JNK-1-IN-4 inhibits the phosphorylation of c-Jun, and reduces the expression of TGF-β1-induced EMT marker proteins, such as fibronectin and α-SMA. JNK-1-IN-4 exhibits good pharmacokinetic characteristics with a bioavailability of 69%. JNK-1-IN-4 exhibits anti-fibrotic effect in Bleomycin (HY-17565)-induced mice idiopathic pulmonary fibrosis models.
Product information
CAS Number: 3047795-60-5
Molecular Weight: 501.38
Formula: C22H25BrN6O3
Chemical Name: 2-({5-bromo-2-[(4-methoxyphenyl)amino]pyrimidin-4-yl}amino)-5-[2-(dimethylamino)ethoxy]benzamide
Smiles: COC1C=CC(=CC=1)NC1=NC(NC2=CC=C(C=C2C(N)=O)OCCN(C)C)=C(Br)C=N1
InChiKey: UBZQKRQTHMVINB-UHFFFAOYSA-N
InChi: InChI=1S/C22H25BrN6O3/c1-29(2)10-11-32-16-8-9-19(17(12-16)20(24)30)27-21-18(23)13-25-22(28-21)26-14-4-6-15(31-3)7-5-14/h4-9,12-13H,10-11H2,1-3H3,(H2,24,30)(H2,25,26,27,28)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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